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Abstract #0764

Simultaneous T2/T2* quantification for oxygen extraction fraction estimation using GE-SE EPIK: A preliminary study in brain tumor patients

Fabian Küppers1,2, Seong Dae Yun1, Philipp Lohmann1, Christian Filss1,3, Gabriele Stoffels1, Karl-Josef Langen1,3, and Nadim Jon Shah1,4,5,6
1Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Jülich, Germany, 2RWTH Aachen University, Aachen, Germany, 3Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany, 4JARA-BRAIN - Translational Medicine, Aachen, Germany, 5Institute of Neuroscience and Medicine - 11, Forschungszentrum Juelich GmbH, Jülich, Germany, 6Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany

Synopsis

Keywords: Multi-Contrast, Oxygenation, Oxygen Extraction FractionThe versatile information provided by simultaneous multi-contrast GE/SE acquisitions keeps interest in this area high. This work extends the previously published 10-echo GE-SE EPIK to investigate brain tumor patients. Within this scope, a single-slice 12-second acquisition provides quantification of T2 and T2* with application to oxygen extraction fraction (OEF) information. Data from four tumor patients were acquired, revealing increased T2/T2* values and increased OEF in regions with variable amino acid uptake in O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET.

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Keywords