Keywords: Data Acquisition, fMRI, Physiological denoising, ABP regulationThe relationship between arterial blood pressure (ABP) fluctuations and the BOLD-fMRI signal is mostly unknown due to the limited availability of reliable MR-compatible ABP devices. Here, we propose a combined experimental and mathematical modeling methodology that uses two calibration recordings outside the scanner to estimate the ABP during the MR scan. Significant correlations between BOLD and ABP were observed in all tested subjects, which also revealed that the global BOLD signal is intrinsically correlated with the underlying ABP fluctuations. Our method is expected to improve our understanding of ABP regulation in the brain and allow for improved physiological fMRI denoising.
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