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Abstract #0769

Biophysical model to correct for blood volume confounders of T2* mapping based renal MR oximetry

Thomas Gladytz1, Kathleen Cantow2, Jason Michael Millward1,3, Sonia Waiczies1,3, Erdmann Seeliger2, and Thoralf Niendorf1,3
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Institute of Translational Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Synopsis

Keywords: Oxygenation, Quantitative ImagingQuantitative MRI of renal hypoxia, an early key feature in acute kidney injury, is a valuable tool for diagnostics and pathophysiological studies. En route to MR oximetry we propose a biophysical model that uses the kidney size as an additional MRI derivable information to correct for blood volume confounders of oxygenation sensitive T2* maps. The model is demonstrated in a preclinical study involving three different vascular occlusions highlighting the confounding effect of blood volume changes and its correction.

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