Abstract #0774
Enlarged Perivascular Spaces in the Basal Ganglia Surround Arteries, not Veins
Jan Oltmer1, Julia Beck2, Hendrik Mattern3,4, Renat Yakupov3,5, Corinne Auger6, Emrah Düzel3,5,7,8, Susanne van Veluw6,9,10, Stefanie Schreiber2,3,5,7, and Valentina Perosa3,9
1Athinoula A. Martinos Center, Massachusetts General Hospital/Harvard medical school, Charlestown, MA, United States, 2Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany, 3German center for neurodegenerative diseases (DZNE), Magdeburg, Germany, 4Department of Biomedical Magnetic Resonance (BMMR), Institute for Physics, Otto-von-Guericke-University, Magdeburg, Germany, 5Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany, 6MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, United States, 7Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany, 8Institute of Cognitive Neuroscience, University College London, London, United Kingdom, 9J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States, 10Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
Synopsis
Keywords: Blood vessels, High-Field MRI, Histopathology
Fluid-filled perivascular spaces (PVS) surround brain vessels. Their enlargement is a common hallmark of cerebral small vessel disease (CSVD) and has been related to impaired clearance of toxic proteins from the brain. It is unclear whether PVS enlarge around arteries, veins, or both. Combining ultra-high resolution 7T MRI angiography, venography and histology, we show that in healthy controls and patients with CSVD, PVS enlarge around arteries more than veins within the basal ganglia. A better understanding of the anatomy and distribution of enlarged PVS can contribute to the understanding of perivascular clearance and disease mechanisms.
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