Keywords: Blood vessels, Rare disease
Gould syndrome is a multisystem disorder whose manifestations are highly variable. Animal studies suggest that allelic heterogeneity and genetic context contribute to the clinical variability. Clinical manifestations associated with Gould syndrome include blood–brain barrier (BBB) leakage, microbleeds, and white matter lesions. Here, we use multimodal MRI at 14.1Tesla to characterize radiological findings observed in mouse models of Gould syndrome caused by mutations in Collagen type IV alpha 1 (Col4a1). We show that multimodal MRI can successfully differentiate between disease subtypes based on anatomical changes as well as prevalence, number, volume and type of brain lesions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords