Abstract #0798

Magnetic resonance fingerprinting for objective and contrast-free focal liver lesion characterization: A preliminary study

Katsuhiro Sano¹, Shohei Fujita^1,2, Gastao Cruz^3,4, Carlos Velasco³, Hideo Kawasaki¹, Yuki Fukumura⁵, Akiyoshi Suzuki¹, Yuichi Morita¹, Koji Kamagata¹, Issei Fukunaga¹, Masami Yoneyama⁶, Ryohei Kuwatsuru¹, Akio Saiura⁷, Kenichi Ikejima⁸, Rene Botnar³, Claudia Prieto³, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan, ³Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ⁴Department of Radiology, University of Michigan, Ann Arbor, MI, United States, ⁵Department of Human Pathology, Juntendo University, Tokyo, Japan, ⁶MR Clinical Science, Philips Japan, Tokyo, Japan, ⁷Department of Hepatobiliary-Pancreatic Surgery, Juntendo University, Tokyo, Japan, ⁸Department of Gastroenterology, Juntendo University, Tokyo, Japan

Synopsis

Keywords: Liver, MR FingerprintingObjective and contrast-free methods for differentiating benign focal liver lesions from malignant lesions (e.g., hepatocellular carcinomas and metastases) are desired. Herein, we evaluated the diagnostic capability of liver magnetic resonance fingerprinting (MRF) in patients with focal liver lesions. Liver MRF provided repeatable T1, T2, T2*, and fat-fraction values for various focal liver lesions. The liver MRF T1 and T2 relaxation times showed high agreement with separate conventional quantitative mapping measurements. Measurements of liver MRF and a combination of MRF relaxation times provided good differentiation of focal liver lesions (AUC of 0.87 for differentiating common benign lesions from common malignant lesions).

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