Abstract #0803

Patient-specific computational model of interstitial fluid flow in pancreatic cancer based on DCE- and DW-MRI

Hooman Salavati^1,2,3, Wim Ceelen^1,3, Charlotte Debbaut^2,3, Clarisse Lecluyse⁴, and Pim Pullens^4,5,6

¹Department of Human Structure and Repair, Ghent University, Ghent, Belgium, ²IBiTech – Biommeda, Ghent University, Ghent, Belgium, ³Cancer Research Institute Ghent (CRIG), Ghent, Belgium, ⁴Department of Radiology, Ghent University Hospital (UZGent), Ghent, Belgium, ⁵Ghent Institute of Functional and Metabolic Imaging (GIFMI), Ghent, Belgium, ⁶IBiTech – Medisip, Ghent University, Ghent, Belgium

Synopsis

Keywords: In Silico, Simulations, Biomechanics

The abnormal interstitial fluid flow (IFF) in solid tumors characterized by the elevated interstitial fluid pressure (IFP) is one of the major barriers for treating solid tumors. Here, we implemented DCE-MRI and IVIM DW-MRI in a clinical study to upgrade the existing basic mathematical framework of IFF to a patient-specific model. The results were compared with the basic model, which showed a noticeable difference regarding the prediction of the heterogeneity of IFF.

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