Keywords: Hyperpolarized MR (Non-Gas), Cancer, animals, preclinical, brain, metabolismTERT expression is essential for telomere maintenance and uncontrolled tumor proliferation in oligodendrogliomas. TERT is an attractive therapeutic target and the drug 6-thio-2’-deoxyguanosine that disrupts telomere maintenance is in clinical trials for cancer. We previously showed that TERT expression is associated with upregulation of the pentose phosphate pathway in oligodendrogliomas. Here, we have established the ability of hyperpolarized δ-[1-13C]-gluconolactone, a probe of the pentose phosphate pathway, to assess TERT expression and response to 6-thio-2’-deoxyguanosine in oligodendrogliomas in vivo. Our findings provide a non-invasive method of imaging a hallmark of cancer and have the potential to improve management of oligodendroglioma patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords