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Abstract #0843

Development for hyperpolarized [1-13C]alpha-ketoglutarate MRI for metabolic imaging of normal volunteers and mutant IDH glioma patients

Yaewon Kim1, Duy Dang1, James Slater1, Andrew Riselli1, Jeremy Gordon1, Susan Chang2, Yan Li1, Evelyn Escobar1, Hsin-Yu Chen1, Chou T Tan3, Chris Suszczynski3, Robert Bok1, and Dan Vigneron1,2
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, 2Department of Neurological Surgery, University of California, San Francisco, CA, United States, 3ISOTEC Stable Isotope Division, MilliporeSigma, Miamisburg, OH, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Non-ProtonHyperpolarized [1-13C]alpha-ketoglutarate (aKG) is a metabolic probe that can provide direct access to the metabolic pathway for glutamate production or 2-HG production in altered alpha-ketoglutarate metabolism via IDH mutations. With its potential to serve as a biomarker of IDH1 mutational status in glioma and a measure of aKG metabolism in normal healthy subjects, we developed a new chemistry preparation and standard operating procedure (SOP) for on-site production of hyperpolarized GMP [1-13C]alpha-ketoglutarate and characterized the probe to investigate the feasibility of this probe in clinical setting. Following process qualification trials with HP [1-13C]aKG, an FDA IND application was prepared and submitted.

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