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Abstract #0846

Beyond lactate: using hyperpolarized [1-13C] pyruvate to measure human brain pH and amino acid metabolism

Alixander S Khan1,2, Joshua Kaggie1,2, Ines Horvat-Menih1,2, Tomasz Matys1, Rolf F Schulte3, Matthew Locke1,2, Ashley Grimmer1,2, Elizabeth Latimer1,2, Amy Frary1,2, Martin Graves1, Mary McLean1,2, and Ferdia Gallagher1,2
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, 3GE Healthcare, GE Healthcare, Munich, Germany

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

Hyperpolarized 13C MRS was used to measure human brain pH for the first time following 13C imaging through measurements of 13CO2 and bicarbonate. Aspartate concentration was also found offering insight into amino acid metabolism. Global brain pH was measured in the brain to be 6.98 ± 0.06. Non-invasive measurements of cerebral pH could be particularly important in assessing cerebral pathology given the wide range of disease processes that alter acid-base balance. Aspartate was measured in 4 of 9 volunteers with no age-related trends seen. Pyruvate carboxylase flux was found to be 6% of pyruvate dehydrogenase flux.

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Abstract Presentation Video

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