Abstract #0849

Incorporating DCE derived perfusion terms to inform fitting of hyperpolarized pyruvate metabolism in a human thyroid tumor.

Christopher M Walker¹, Renjie He², Zhan Xu¹, Keith Michel¹, Gary Martinez¹, Collin J. Harlan¹, Abdallah S. R. Mohamed², Clifton D. Fuller ², Stephen Y. Lai³, and James A Bankson¹

¹Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, ²Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States, ³Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)Dynamic contrast enhanced MRI was used to derive perfusion terms which were incorporated into the fitting of hyperpolarized pyruvate to lactate apparent conversion rates. Incorporation of the DCE data reduced the fit metabolic conversion rates across the data set but more so for the post therapy data resulting in a significant decrease in kpl after therapy. These results suggest that more effort is needed to disentangle perfusion from metabolic effects when analyzing HP MRI data.

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