Abstract #0851

Multi-Voxel PRESS of Hyperpolarized 13C-labelled Agents In Vivo

Wolfgang Gottwald¹, Irina Heid², Luca Nagel¹, Martin Grashei¹, Sebastian Bauer¹, Mariia Semina², Nadine Setzer¹, Sandra Suehnel¹, Geoffrey J. Topping¹, Rickmer Braren^2,3, and Franz Schilling¹

¹TUM School of Medicine, Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany, ²TUM School of Medicine, Institute of Diagnostic and Interventional Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany, ³German Cancer Consortium (DKTK, partner Site Munich), Munich, Germany

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

A newly developed multi-voxel point resolved spectroscopy (MV-PRESS) sequence was evaluated for the study of murine pancreatic ductal adenocarcinoma (PDAC) using hyperpolarized (HP) ¹³C-labelled molecules. First, the sequence was compared to standard 2D free-induction decay chemical shift imaging (2D FID-CSI) in vivo using HP [1-¹³C]pyruvate (PA). Then, multiple ROIs in mice with endogenous PDAC were selected based on anatomical ¹H imaging. From those voxels, high resolution spectra using the MV-PRESS sequence were acquired to evaluate differences in pyruvate-to-lactate conversion. Finally, the sequence was used to determine the extracellular pH of tumor lesions and kidneys in the same animal model.

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