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Abstract #0852

High-throughput kinetic analysis in a microfluidic multiwell platform by dissolution dynamic nuclear polarization-magnetic resonance

Marc Azagra1, Jose Yeste Lozano1, Maria Alejandra Ortega 1, Alejandro Ernesto Portela1, Gergö Matajsz1, Alba Herrero Gómez1, Kim Yaewon2, Renuka Sriram2, John Kurhanewicz2, Daniel Vigneron2, and Irene Marco Rius1
1MIPMED, IBEC, Barcelona, Spain, 2UCSF, San Francisco, CA, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), New Devices, dissolution DNP, MRSI, microfluidics, multisample measurementHigh throughput dissolution Dynamic Nuclear Polarization (dDNP) magnetic resonance spectroscopic imaging (MRSI) was achieved by developing a multiwell microfluidic platform. This platform allows for multiple experiments to be performed with a single injection of a dDNP substrate, enabling faster and more reproducible data gathering, reducing experimental costs and time by a factor of 8. Here, we present a proof of concept of the methodology with an oxidation reaction combining [1-13C]pyruvic acid with hydrogen peroxide, testing 2 different conditions with 3 replicates each.

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Keywords