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Abstract #0854

Over 20% 13C-Hyperpolarization and Fast Imaging of Ethyl-[1-13C]-Acetate-d6 and Ethyl-[1-13C]-Pyruvate-d6 using SAMBADENA

Obaid Mohiuddin1, Henri de Maissin1,2, Marvin Herzog1,2, Andrey Pravdivtsev3, Arne Brahms4, Eduard Y. Chekmenev5,6, Rainer Herges4, Jan-Bernd Hövener3, Maxim Zaitsev1, Dominik von Elverfeldt1, and Andreas Benjamin Schmidt1,2,5
1Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Frieburg, Freiburg, Germany, 2German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, Kiel, Germany, 4Otto Diels Institute for Organic Chemistry, Kiel University, Kiel, Germany, 5Chemistry, Wayne State Univeristy, Detroit, MI, United States, 6Russian Academy of Sciences (RAS), Moscow, Russian Federation

Synopsis

Keywords: High-Field MRI, Hyperpolarized MR (Non-Gas), ParahydrogenParahydrogen is a cost-efficient source of spin order for high-throughput production of hyperpolarized contrast agents. The parahydrogen approach SAMBADENA has shown great potential for biomedical applications: agents are polarized in situ in the MRI system at low cost with little additional hardware, repeatedly every 15s, and administration in vivo has been demonstrated. Here we present a new setup and high 13C polarization of 28% or 19% for ethyl-[1-13C]-acetate-d6 and ethyl-[1-13C]-pyruvate-d6, respectively, at concentrations of up to 80mM. We envision SAMBADENA to become a versatile method for the widespread application of hyperpolarized MRI and high throughput metabolic 13C MRI studies.

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