Abstract #0855

Nonpersistent broad-linewidth radicals generated using a 6 MeV linear electron accelerator for application in Dynamic Nuclear Polarization

Catriona H. E. Rooney¹, Justin Y. C. Lau², Brett W. C. Kennedy¹, Alice M. Bowen³, William K. Myers⁴, Iain D. C. Tullis⁵, Kristoffer Petersson⁵, Jack J. J. J. Miller^1,6,7,8, and Damian J. Tyler^1,8

¹Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ²GE Healthcare, Schenectady, NY, United States, ³Department of Chemistry and Photon Science Institute, University of Manchester, Manchester, United Kingdom, ⁴Centre for Advanced ESR, University of Oxford, Oxford, United Kingdom, ⁵MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, ⁶Department of Physics, University of Oxford, Oxford, United Kingdom, ⁷The MR Research Centre, Aarhus University, Aarhus, Denmark, ⁸Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Contrast AgentStable free radicals formed in solid-state alanine (an established dosimeter) when exposed to ionizing radiation may be exploited to enable Dynamic Nuclear Polarization (DNP). Here, we used 6 MeV electron irradiation to generate nonpersistent radicals for the hyperpolarization of sterilized ¹³C-alanine. Electron Paramagnetic Resonance (EPR) confirmed radical formation, linear with dose up to 70 kGy. DNP build-up was demonstrated for solid ¹³C-alanine irradiated to 100 kGy. The broad EPR spectrum suggests the need for microwave frequency modulation to fully exploit the radiation induced nonpersistent radicals. However, this novel methodology makes DNP of solid substrates without a glassing agent possible.

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