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Abstract #0856

Compressed sense reconstructions improve non-Cartesian hyperpolarized 129Xe MRI

Joseph W Plummer1,2, Abdullah S Bdaiwi1,2, Stephanie A Soderlund1, Matthew M Willmering1, Jason C Woods1,3,4,5, Zackary I Cleveland1,2,4,5, and Laura L Walkup1,2,4,5
1Center for Pulmonary Imaging Research, Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Department of Physics, University of Cincinnati, Cincinnati, OH, United States, 4Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 5Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Synopsis

Keywords: Hyperpolarized MR (Gas), Image ReconstructionHyperpolarized 129Xe MRI is a powerful pulmonary imaging modality to assess regional ventilation, gas exchange, and lung microstructure. However, non-equilibrium magnetization decay and relatively long breath-hold durations remain major limitations to routine clinical dissemination. While non-Cartesian sampling methods can improve sampling efficiency, these methods are yet to be combined with non-linear reconstruction methods like compressed sensing to further increase speed and reduce image noise. Here, we implement compressed-sense reconstructions across a range of non-Cartesian 129Xe MRI techniques and show that SNR and image quality can all be improved while reducing scan time.

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Keywords