Abstract #0875

The role of FK506 binding protein 5 in the early development of ischemic lesion using multi-parametric MRI

Zih-Rong Lai¹, Yu-Ping Kang², Chia-Feng Lu¹, Bao-Yu Hsieh^3,4, Yi-Hsuan Lee^2,5, and Yu-Chieh Jill Kao¹

¹Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ³Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴partment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ⁵Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan

Synopsis

Keywords: Stroke, Preclinical, Transgenic miceTo explore how the FK506 binding protein 5 (FKBP5) affect the ischemic stroke outcome, we employed Fkbp5-knock out (KO) mice and evaluated the ADC- and CBF-deficit volume, as well as angiography in the acute phase and the final lesion volume at 24 hours after the occlusion of middle cerebral artery (MCAO). The discent lesion volume and loss of collaterals after MCAO in the Fkbp5-KO animals suggested the early determination of the stroke outcome in the Fkbp5-KO animals after ischemic insult.

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