Abstract #0876

Cerebrovascular reactivity is a predictor of small vessel disease severity after one year in patients with mild stroke

Emilie Sleight^1,2, Michael S Stringer^1,2, Una Clancy^1,2, Carmen Arteaga^1,2, Daniela Jaime Garcia^1,2, Will Hewins^1,2, Angela CC Jochems^1,2, Rachel Penman^1,2, Yajun Cheng^1,2,3, Dillys Liu^1,2,4, Junfang Zhang^1,2,5, Iona Hamilton⁶, Charlotte Jardine⁶, Rosalind Brown^1,2, Eleni Sakka^1,2, Agniete Kampaite^1,2, Stewart Wiseman^1,2, Maria Valdes-Hernandez^1,2, Francesca Chappell^1,2, Fergus Doubal^1,2, Ian Marshall^1,2, Michael J Thrippleton^1,2,6, and Joanna M Wardlaw^1,2,6

¹Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, ²UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom, ³Department of Neurology, West China Hospital of Sichuan University, Chengdu, China, ⁴Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Neurology, Shanghai Jiao Tong University, Shanghai, China, ⁶Edinburgh Imaging Facility RIE, University of Edinburgh, Edinburgh, United Kingdom

Synopsis

Keywords: Stroke, Blood vessels, Cerebrovacular reactivitySmall vessel disease (SVD) causes stroke and dementia, but its pathogenesis remains poorly understood. We measured cerebrovascular reactivity (CVR) in SVD patients with minor stroke using 3T BOLD MRI and investigated its relation to baseline and progression of SVD features after one year adjusting for age and vascular risk factors. Patients with lower CVR had higher baseline white matter hyperintensity (WMH) volume, more lacunes and microbleeds and lower brain volume. After one year, patients with lower baseline CVR had increased WMH burden. In conclusion, CVR impairment in SVD patients is associated with higher SVD burden and predicts worsening of SVD.

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