Abstract #0879

White Matter Reactivity to Hemodynamic Stimuli: Insights from Dynamic and Maximal Cerebrovascular Reserve after Acetazolamide Provocation

James Michael Gee¹, Xiuyuan Wang², Siddhant Dogra¹, Jelle Veraart¹, Koto Ishida³, Deqiang Qiu⁴, and Seena Dehkharghani^1,3

¹Radiology, New York University, New York, NY, United States, ²Radiology, Weill Cornell Medical College, New York, NY, United States, ³Neurology, New York University, New York, NY, United States, ⁴Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States

Synopsis

Keywords: White Matter, fMRI (resting state), Cerebrovascular reactivityWe explored cerebrovascular reactivity (CVR) of white matter in patients with evidence for micro- and macrovascular disease using our previously described Blood Oxygen Level Dependent – acetazolamide paradigm. Subjects consistently demonstrated lower CVR in voxels with microangiopathic white matter when present in hemispheres with coexistent proximal, large-vessel steno-occlusive disease (SOD). The relationship of CVR values in normal appearing white matter and contralateral white matter lesions in patients with unilateral SOD is more complex and warrants further investigation.

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