Abstract #0881

Quantification of oxygen metabolism in acute ischemic stroke with multi-parametric quantitative BOLD MRI

Hongwei Li¹, Ying-Hua Chu², Yu Luo³, and He Wang^1,4,5

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²MR Collaboration, Siemens Healthineers Ltd., Shanghai, China, ³Department of Radiology, Shanghai Fourth People's Hospital Affiliated to TongjiUniversity School of Medicine, Shanghai, China, ⁴Human Phenome Institute, Fudan University, Shanghai, China, ⁵Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Stroke, OxygenationMulti-parametric quantitative BOLD (Mq-BOLD), a biophysical model-based technology, has shown promising results for measuring brain oxygenation in healthy subjects. Our purpose is to explore Mq-BOLD in evaluating the changes of oxygen metabolism in early stage of acute ischemic stroke. There is compensatory elevated oxygen extraction fraction (OEF) in the hypoperfused tissue, but decreased cerebral metabolic rate of oxygen (CMRO2) present in the central part of the infarct core. These alternative biomarkers may provide intuitive diagnostic information of ischemic penumbra in stroke. Moreover, Mq-BOLD only depends on standard clinical imaging protocols, which has a great potential for future routine application.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.