Abstract #0883

Microvascular response of an oxygen carrier in the penumbral tissue of fast and slow progressors in a canine large vessel occlusion model

Mohammed Salman Shazeeb¹, Robert King¹, Zeynep Vardar¹, Josephine Kolstad¹, Anna Kuhn¹, Vania Anagnostakou¹, Christopher Raskett¹, Jonathan Winger², Ana Krtolica³, Nils Henninger¹, and Matthew Gounis¹

¹University of Massachusetts Chan Medical School, Worcester, MA, United States, ²Omniox, Inc., Palo Alto, CA, United States, ³Oryn Therapeutics, Redwood City, CA, United States

Synopsis

Keywords: Stroke, Diffusion/other diffusion imaging techniquesIn acute ischemic stroke due to large vessel occlusion (LVO), information about the penumbral tissue can be vital in making decisions on how to treat ischemic stroke patients in the clinic. This study investigated the use of intravoxel incoherent motion (IVIM) MRI in a canine LVO model to quantify the perfusion information in penumbral tissue of fast and slow progressors that received an oxygen carrier drug. The IVIM parameters were assessed to predict the onset of penumbral tissue death. The IVIM parameters showed a better utility in predicting penumbral tissue death in fast progressors compared to slow progressors.

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