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Abstract #0884

Quantitative evaluation of mannitol induced effects on ischemic rat brains using free water elimination and mapping with explicit T2 attenuation

Chia-Wen Chiang1, Ezequiel Farrher2, Kuan-Hung Cho1, Sheng-Min Huang1, N. Jon Shah2,3,4,5,6, Chang-Hoon Choi2, and Li-Wei Kuo1,7
1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 2Institute of Neuroscience and Medicine – 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, 3Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 4JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany, 5Institute of Neuroscience and Medicine – 11, Forschungszentrum Jülich, Jülich, Germany, 6Monash University, Melbourne, Australia, 7National Taiwan University College of Medicine, Taipei, Taiwan

Synopsis

Keywords: Stroke, TreatmentCerebral edema occurs after stroke. Mannitol is commonly used dehydrating agent for effectively improving cerebral edema. However, the edema state after mannitol administration and its effectiveness at the post-acute stages remain unclear. Recently, we have demonstrated free-water elimination and mapping (FWET2) can be used to characterize vasogenic edema in stroke animal models. The aim of this study was to quantitatively evaluate mannitol-induced effects on ischemic rat brains at different time points by using FWET2. We attempted to examine if free water fraction change could reflect mannitol-induced effects on infraction and correlate free water fraction change with total infarct volume.

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