Keywords: Stroke, fMRI (resting state), deep brain stimulationTo improve reproducibility of positive outcomes from cerebellar dentate stimulation for chronic stroke, we hypothesized that the volume of tissue activated (VTA) (dentateVTA) proximity to the volume functionally connected to ipsilesional motor-associated cortices (dentateFC-ipsi-motor) would be associated with improved arm impairment/function metrics. DentateVTA was estimated using computed tomography and T1-weighted MRI. DentateFC-ipsi-motor was estimated from fMRI (resting state). Significant correlations with arm metric improvement were not found for dentateVTA proximity to dentateFC-ipsi-motor, but were found for dentateVTA size, distance from center, and percentage VTA in the inferior-lateral-posterior region. These findings suggest stimulating a small target at the inferior-posterior-lateral dentate edge.
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