Abstract #0888

Mapping the vascular reserve in white matter and basal ganglia using Ferumoxytol-enhanced MRI at 7T

Chenyang Li^1,2, Li Jiang¹, Zhe Sun^1,2, Marco Muccio¹, Yongsheng Chen³, Sagar Buch³, E.Mark Haacke⁴, Jiangyang Zhang¹, and Yulin Ge¹

¹Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, ²Vilcek Institute of Graduate Biomedical Sciences, NYU Grossman School of Medicine, New York, NY, United States, ³Department of Neurology, Wayne State University School of Medicine, Detroit, MI, United States, ⁴Department of Radiology, Wayne State University School of Medicine, Detroit, MI, United States

Synopsis

Keywords: Blood vessels, Susceptibility, Cerebral blood volumeIn this work, we use high resolution susceptibility weighted imaging (SWI) and ΔR2* to investigate the cerebral blood volume (CBV) in white matter tracts and basal ganglia after the administration of blood-pool contrast agent Ferumoxytol. Utilizing the merit of ultrahigh field and strong T1 and T2* shortening contrast agent, we further probe the effect of microvascular density on capillary CBV in white matter tracts and basal ganglia, which provides additional insights to the vascular reserve at capillary level in white matter and basal ganglia.

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