Abstract #0889

Simultaneous PET/MRI can measure extracellular pH in the tumor microenvironment

Alyssa C Pollard^1,2, Jorge de la Cerda¹, F William Schuler¹, Tyler R Pollard¹, Aikaterini Kotrotsou¹, Loreno Palagi³, Chetan Dhakan¹, Federica Pisaneschi¹, and Mark D Pagel⁴

¹Department of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States, ²Department of Chemistry, Rice University, Houston, TX, United States, ³Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy, ⁴Department of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: PET/MR, Contrast Agent, pH imagingAcidosis is a useful biomarker for tumor diagnoses and for evaluating early response to anti-cancer treatments. T1-based MRI contrast agents have been developed with a r1 relaxivity that is responsive to extracellular pH (pHe) in the tumor microenvironment. However, the concentration of these agents in the tumor must also be known to determine r1 relaxivity. We have developed PET/MRI co-agents that can be evaluated with simultaneous PET/MRI during pre-clinical studies with mouse models of human cancers. The PET agent reports on the concentration of the agents, which can be used to determine r1 relaxivity and estimate pHe in tumors.

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