Abstract #0893

Amide proton transfer image corrected by apparent diffusion coefficient improved diagnostic accuracy in grading brain tumors on a PET/MR system

Koji Sagiyama¹, Osamu Togao², Takeshi Kamitani¹, Koji Yamashita³, Yuzo Yamasaki¹, Kazufumi Kikuchi¹, Takuya Hino¹, and Kousei Ishigami¹

¹Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Department of Radiology Informatics and Network, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Synopsis

Keywords: Tumors, PET/MR, Amide Proton Imaging, Apparent Diffusion Coefficient, ADCAmide proton transfer (APT) imaging is useful for grading brain tumors; however, its diagnostic accuracy is compromised by the heterogeneity of the tumor's structure. In this study, we investigated using a PET-magnetic resonance (PET/MR) system whether dividing the APT by the apparent diffusion coefficient (ADC) improves the diagnostic ability of high-grade and low-grade brain tumors by correcting for the effects of tissue structure. The corrected APT (APT/ADC) showed the best diagnostic performance in grading brain tumors compared to APT, ADC, and standardized uptake value (SUV) alone.

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