Abstract #0894
Oxygen-Enhanced MRI Assessment of Radiotherapy-Induced Treatment Effects in Patients with Head and Neck Cancer
Michael J Dubec1,2, John Gaffney3, David L Buckley2,4, Michael Berks1, Anubhav Datta1,5, Damien J McHugh1,2, Ross A Little1, Susan Cheung1, Christina Hague3, Julian C Matthews6, Ananya Choudhury1,3, Marcel van Herk1, Andrew McPartlin7, Geoff JM Parker8,9, and James PB O'Connor1,5,10
1Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 2Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom, 3Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom, 4Biomedical Imaging, University of Leeds, Leeds, United Kingdom, 5Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom, 6Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 7Radiation Medicine, Princess Margaret Cancer Centre, Toronto, ON, Canada, 8Bioxydyn Ltd, Manchester, United Kingdom, 9Centre for Medical Image Computing, University College London, London, United Kingdom, 10Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom
Synopsis
Keywords: Cancer, Head & Neck/ENT, Tumour Hypoxia, Radiotherapy, OE-MRI, MR LinacHypoxia is common to most solid tumours and mediates treatment resistance. Oxygen-enhanced (OE)-MRI can identify, map and quantify hypoxia in multiple tumour types including H&N cancer. We build upon previous work to show that OE-MRI biomarkers: (i) can be deployed on multiple MRI systems; (ii) are repeatable; (iii) can detect cohort level response to radiotherapy; (iv) can identify which individual lesions have significant changes in their oxygenation, hypoxic volume and hypoxic fraction.
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