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Abstract #0895

In-Vivo Simultaneous Hyperpolarized 129Xe MRI and [15O]-water PET Multi-Modal Imaging: A Proof of Concept Study

Ramanpreet K. Sembhi1, Matthew S. Fox1,2, Heeseung Lim2,3, Justin W. Hicks2,4, Shawn N. Whitehead5, Jonathan D. Thiessen2,4, Grace Parraga4,6, and Alexei V. Ouriadov1,2,7
1Department of Physics and Astronomy, The University of Western Ontario, London, ON, Canada, 2Lawson Health Research Institute, London, ON, Canada, 3Siemens Healthcare Limited, London, ON, Canada, 4Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada, 5Department of Anatomy and Cell Biology, The University of Western Ontario, London, ON, Canada, 6Robarts Research Institute, London, ON, Canada, 7School of Biomedical Engineering, The University of Western Ontario, London, ON, Canada

Synopsis

Keywords: PET/MR, Hyperpolarized MR (Gas)In this proof-of-concept study, simultaneous 129Xe-based MRI and [15O]-water PET images were collected and compared from rat brain. For initial validation phase in phantoms, we have dissolved 129Xe in [15O]-water to simultaneously use both imaging modalities and confirm that PET/MRI images reflect the true density of the 15O/129Xe. The comparison results show similarity between both imaging modalities and tracers, moving towards the next step in validating the Xenon imaging technique as a potential for brain perfusion measurement. The acquisitions were carried out using a 3T PET/MRI (Siemens Biograph mMR).

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