Abstract #0899

Relaxation-compensated CEST-MRI at 3 T exhibits regional differences in gray matter and white matter contrasts of glioma patients

Florian Kroh^1,2, Philip S. Boyd¹, Nikolaus von Knebel Doeberitz³, Heinz-Peter Schlemmer^3,4, Mark E. Ladd^1,2,4, Peter Bachert^1,2, Daniel Paech^3,5, and Andreas Korzowski¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, ⁵Division of Neuroradiology, University Hospital Bonn, Bonn, Germany

Synopsis

Keywords: CEST & MT, Brain

In this study, the APT-weighted (APTw_asym) and relaxation-compensated CEST-MRI contrasts of 9 postoperative glioma patients, were analyzed for potential regional differences in gray and white matter. The purpose of this analysis was to identify the influence of the location within the brain on CEST contrasts of tumorous and healthy control tissue, respectively. For relaxation-compensated CEST (MTR_Rex), (i) differences between gray and white matter and also (ii) regional differences with a decreased contrast inside the frontal lobe were found. On the contrary, the APTw_asym was found to be independent of (i) location and (ii) comparable for gray and white matter.

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