Abstract #0900

Highly Accelerated 3D EPI CEST Imaging using Unevenly Segmented RF Irradiation with Temporal Random Walk Sampling Pattern in a Brain Tumor Patient

Hahnsung Kim^1,2, Suhyung Park^3,4, Ranliang Hu², Kimberly B Hoang⁵, and Phillip Zhe Sun^1,2

¹Emory National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ³3Department of Computer Engineering, Chonnam National University, Gwangju, Korea, Republic of, ⁴Department of ICT Convergence System Engineering, Chonnam National University, Gwangju, Korea, Republic of, ⁵Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States

Synopsis

Keywords: CEST & MT, CEST & MTWe proposed a new 3D EPI CEST imaging integrated with unevenly segmented RF irradiation configuration to reduce T_1w relaxation-induced signal modulation, thereby allowing for a reliable CEST effect over the whole volume. In addition, a temporal random walk with variable density (VD) CAIPI undersampling is incorporated into segmented 3D EPI for optimized random encoding in CEST imaging. The proposed pulse sequence and reconstruction framework were validated on the phantom and tumor patient.

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