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Abstract #0901

Dynamic glucose e­nhanced MRI of gliomas: a preliminary clinical application.

Jianhua Mo1, Xiang Xu2,3, Andong Ma1, Mingjun Lu1, Xianlong Wang1, Qihong Rui1, Jianbin Zhu1, Haitao Wen1, Genyun Lin1, Chen Zhao4, Linda Knutsson3,5,6, Peter van Zijl3,6, and Zhibo Wen1
1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou,Guangdong, China, 2BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Philips Healthcare, Guangzhou, China, 5Department of Medical Radiation Physics, Lund University, Lund, Sweden, 6F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: CEST & MT, Contrast Agent, glucose

In this study, we explored the feasibility of dynamic glucose enhanced (DGE) MRI technology in the clinical application of gliomas. 20 glioma patients underwent pre-operative DGE-MRIs before clinical intervention. We observed a significant increase in DGE area under the uptake curve (AUC) signal in tumors compared to the white matter. In some cases, we found enhancement in DGE MRI in histopathological confirmed tumor region that was not enhanced by Gd T1w MRI. These findings provide a new perspective for the further exploration and analysis of the D-glucose delivery, uptake and metabolism in brain tumors.

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Abstract Presentation Video

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