Keywords: CEST & MT, CEST & MT, gluCEST and glucoCESTHuntington’s disease (HD) is an inherited neurodegenerative disease characterized by motor, cognitive and psychiatric symptoms. As glutamate has been shown to be a potential biomarker of neurodegenerative diseases, we used Chemical Exchange Saturation Transfer imaging of glutamate (gluCEST) to map cerebral glutamate distribution in a rat model of HD. Modification of glutamate levels observed at 12 months were preceded by decrease of lactate concentration and reduced glycolytic metabolism measured glucoCEST at 4 months, suggesting early remodeling of energy metabolism during asymptomatic stage.
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