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Abstract #0903

Ultrafast Z-spectroscopic Imaging in vivo at 3T using through-slice spectral encoding (TS-UFZ)

Chongxue Bie1,2,3, Peter C. M. van Zijl1,2, Deng Mao1,4, and Nirbhay N. Yadav1,2
1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, BALTIMORE, MD, United States, 2The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 3Department of Information Science and Technology, Northwest University, Xi’an, China, 4Philips Healthcare, Baltimore, MD, United States

Synopsis

Keywords: CEST & MT, CEST & MTAcquisition of high-resolution Z-spectra requires excessive scan times. Ultrafast Z-spectroscopy (UFZ) can obtain whole Z-spectra within one acquisition by encoding the Z-spectral dimension spatially via a gradient applied concurrently with the saturation RF pulse, significantly reducing the scanning time. Still, UFZ has had limited success in vivo due to tissue heterogeneity. Here, we developed a TS-UFZ imaging approach where both saturation gradient and its readout were applied in the slice direction, where there is minimal heterogeneity. Results show that TS-UFZ allows high spectral- and spatial-resolution imaging of CEST signals in phantoms and human brain at 3T.

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