Abstract #0904

Fluid-Suppressed APTw is more accurate than Leakage-Corrected rCBV imaging in the distinction between tumor progression and radionecrosis

Lucia Nichelli^1,2, Christos Papageorgakis³, Mehdi Bensemain⁴, Julian Jacob^2,5, Charles Valery⁶, Patrick Liebig⁷, Moritz Zaiss⁸, Stéphane Lehéricy^1,2, and Stefano Casagranda³

¹Department of Neurosurgery, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière-Charles-Foix, Paris, France, ²Sorbonne University, ICM, Paris, France, ³Department of R&D Advanced Applications, Olea Medical, La Ciotat, France, ⁴Department of Radiology, Nancy Regional University Hospital Centre, Nancy, France, ⁵Department of Radiation-Oncology, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié- Salpêtrière-Charles-Foix, Paris, France, ⁶Department of Neurosurgery, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié- Salpêtrière-Charles-Foix, Paris, France, ⁷Siemens Healthcare GmbH, Erlangen, Germany, ⁸Department of Neuroradiology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Synopsis

Keywords: CEST & MT, Tumor, APTw Imaging, Perfusion, Metastases, Radionecrosis, Tumor ProgressionThe distinction between radionecrosis and tumor recurrence is a common diagnostic dilemma, as current advanced multiparametric MRI protocols lack on accuracy. Fluid-Suppressed Amide Proton Transfer weighted (APTw) imaging has strong potentials in brain tumor post-therapeutic assessment. In this study we compare at 3T the diagnostic accuracy of Fluid Suppressed APTw with the most used advanced technique, i.e. the Leakage-Corrected relative Cerebral Blood Volume imaging obtained by DSC perfusion in 22 pre-irradiated metastases. Results show that Fluid-Suppressed APTw metrics can clearly make a distinction between these two pathologies, in contrast to Leakage-Corrected rCBV contrast.

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