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Abstract #0906

An Analytic Solution for the Modified WASABI Method: Application to Simultaneous B0, B1 and T1 Mapping and Correction of CEST MRI

Patrick Schuenke1, Felix Frederik Zimmermann1, Kerstin Kaspar1, Moritz Zaiss2, and Christoph Kolbitsch1
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Institute for Neuroradiology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

Synopsis

Keywords: CEST & MT, Data ProcessingCEST MRI provides a contrast sensitive to exchange processes between solute and water protons that was proven to add value in clinical MRI. However, the contrast is susceptible to B0- and B1 field inhomogeneities as well as the T1 relaxation time. Here we present an analytical solution for a modified WASABI method that enables the quantitative mapping of all three parameters simultaneously from a single CEST-like MRI scan. We show that the generated parameter maps and reference maps match well and demonstrate their applicability for the B0, B1 and T1 correction of CEST MRI data.

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Keywords