Abstract #0907
Validate your CEST simulation!
Patrick Schuenke1, Kai Herz2,3, Zhongliang Zu4, Nirbhay Yadav5,6, Qing Zeng5,6, Markus Huemer7, Rudolf Stollberger7, Jiadi Xu5,6, Kexin Wang5,8, Feriel Romdhane9, Dario Livio Longo9, Or Perlman10, Peter C.M. van Zijl5,8, and Moritz Zaiss11
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 3Department of Biomedical Magnetic Resonance, University of Tuebingen, Tuebingen, Germany, 4Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, 5FM Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 6Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Institut of Bioimaging, Graz University of Technology, Graz, Austria, 8Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 9Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), Torino, Italy, 10Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 11Institute for Neuroradiology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
Synopsis
Keywords: CEST & MT, Simulations, validation, comparisonQuantitative CEST approaches can provide access to the exchange rate and solute concentration of exchange processes of interest. However, differences in the implementation of underlying Bloch-McConnell simulations will lead to differences in the determined quantitative parameters. Thus, we initiated a platform to compare and validate the CEST simulations from various CEST research groups. In this first comparison of continuous-wave saturation schemes, up to 5 different results for 8 compared simulations were observed. The project is still open for participation and we invite everbody to join the comparison and our planned discussions to finally realize a consensus on CEST simulations.
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