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Abstract #0908

Removal of lipid artifacts in CEST data using differential analysis with fitted magnetization transfer and lipid signals (DIGITAL)

Zhechuan Dai1, Xingwang Yong1, Jing Zhang2, Xiaoxia Wang2, Qing Li3, Yi Sun3, Ying Cao4, Jiuquan Zhang2, and Yi Zhang1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China, 3MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, 4School of Medicine, Chongqing University, Chongqing, China

Synopsis

Keywords: CEST & MT, CEST & MTChemical exchange saturation transfer (CEST) imaging provides important molecular information that can reflect changes in various pathologies. However, applying CEST to lipid-rich organs, such as the breast, is technically challenging, where the lipid artifacts can grossly affect the CEST signal. In this study, we propose a novel differential analysis method with fitted magnetization transfer and lipid contributions (DIGITAL) to remove the lipid artifacts without changing the acquisition sequence. The DIGITAL method was validated on breast cancer patients, and yielded fewer lipid artifacts and better image smoothness than previous analysis-based methods.

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Keywords