Abstract #0916

Investigating the Direct Imaging of Neuronal Activity (DIANA) contrast mechanism using human brain organoids

Sean Morrison¹, Ewald Webber², Carl Dixon³, Donald Maillet³, Ernst Wolvetang¹, and Martijn A. Cloos³

¹Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Australia, ²School of Information Technology and Electrical Engineering, University of Queensland, St Lucia, Australia, ³Centre for Advanced Imaging, University of Queensland, St Lucia, Australia

Synopsis

Keywords: Contrast Mechanisms, fMRI, DIANAHere we describe our initial results investigating DIANA’s ability to capture neuronal activation in humans brain organoids. Following drug delivery a 3min long window with 0.5% increased signal was observed. Although tantalising, further experiments are needed to confirm these results.

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