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Abstract #0917

In vivo Detection of Changes in Membrane Potential in Rat Cortex by T2 mapping

Kyeongseon Min1, Sungkwon Chung2, Seung‐Kyun Lee3, Jongho Lee1, Tan Toi Phan4,5, Daehong Kim6, and Jang-Yeon Park4,5
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, Korea, Republic of, 3GE Global Research, Niskayuna, NY, United States, 4Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 5Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, 6National Cancer Center, Goyang, Korea, Republic of

Synopsis

Keywords: fMRI, Contrast Mechanisms

Membrane potential is the crucial element of neuronal activation. We investigated the possibility of using MRI to detect the depolarization of membrane potential in rat cortex. To directly access brain cells, a craniotomy was performed to make a burr hole on the skull. T2 change in the exposed cortex was measured while depolarizing it by directly perfusing artificial cerebrospinal fluid of high potassium concentration. Our findings showed that T2 value of depolarized cortex increased by +2.7% at [K+] = 80 mM. This observation demonstrates that changes in membrane potential are detectable with MRI by T2 contrast in vivo.

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Abstract Presentation Video

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