Abstract #0918

Correlation of zero echo time MB-SWIFT fMRI with neuronal activity during sensory stimulation in anesthetized and awake rats

Juha Valjakka¹, Jaakko Paasonen¹, Raimo A. Salo¹, Ekaterina Paasonen¹, Irina Gureviciene¹, Mikko Kettunen¹, Djaudat Idiyatullin², Shalom Michaeli², Silvia Mangia², Heikki Tanila¹, and Olli Gröhn¹

¹A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: fMRI, Brain, Zero echo time

Zero echo time (ZTE) fMRI with MB-SWIFT poses an artefact free alternative to traditional EPI-based BOLD fMRI approaches. However, the exact origin of the fMRI signal captured with ZTE is unknown. In this work, we investigated the correlation between electrical brain activity and the ZTE fMRI signal during sensory stimulation in anesthetized and awake rats. It is shown that a linear model explains the relationship between the fMRI signal and electrical activity in anesthetized but not in awake rats. We conclude that MB-SWIFT fMRI provides a good proxy for neuronal activity under conventional experimental conditions.

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