Abstract #0919

Direct detection of neural activity in humans by ultrafast high-sensitivity SLAM MRI at 3T

Yi Zhang^1,2, Peiying Liu², Wenqi Wang¹, Deng Mao³, and Paul Bottomley²

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science at Zhejiang University; and the Department of Radiology, Children’s Hospital, Zhejiang University, Hangzhou, China, ²Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³Philips Healthcare, Cleveland, OH, United States

Synopsis

Keywords: fMRI, fMRIThe direct MRI detection of neural activity in humans is a long-sought goal that has been attempted by many. We posit that a key reason for prior failures is inadequate sensitivity. Spectroscopy with linear algebraic modeling (SLAM) is a compartmental imaging method that provides enormous gains in speed and signal-to-noise ratio (SNR). Here we use it to directly obtain MRI signals from arbitrarily-shaped brain regions with arguably the highest possible SNR efficiency. We successfully detect neural responses elicited by rhythmic finger-tapping at the tapping frequency in humans at 3T, as confirmed by simultaneously-acquired EEG data.

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