Abstract #0961

Automatic segmentation of cortical cytoarchitectonic domains measured with high-resolution MAP-MRI

Kristofor Pas¹, Kadharbatcha Saleem¹, Peter J Basser¹, and Alexandru V Avram^1,2,3

¹Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ²Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States, ³Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, United States

Synopsis

Keywords: Microstructure, Gray Matter, MAP-MRI, cortical parcellation, cortical layersWe investigate the feasibility of using advanced diffusion MRI, specifically MAP-MRI, to automatically segment microstructural domains based on subject-specific intrinsic cortical cytoarchitectonic features. Our preliminary results suggest that MAP-derived cytoarchitectonic domains delineate boundaries between cortical areas and layers in good agreement with histology. Segmentation methods that leverage the sensitivity of high-resolution MAP parameters to cortical cytoarchitecture have the potential to augment and refine current techniques for automatic cortical parcellation that rely on atlas registration.

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