Abstract #0966

Permeability mapping in stroke via diffusion Standard Model with Exchange and S/V measurements from high-frequency OGSE

Noam Shemesh¹, Rita Alves², Jonas Olesen^3,4, Andrada Ianus¹, and Sune Nørhøj Jespersen^3,4

¹Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal, ²Champalimaud Foundation, Lisbon, Portugal, ³Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁴Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Contrast Mechanisms, MicrostructureMembrane permeability plays an important role in numerous physiological processes ranging from cell volume regulation to neural activity. Until now, diffusion MRI measurements mainly provided information on exchange rates; however, to map permeability, information on the surface-to-volume (S/V) ratio is needed. Here, we apply ultrahigh frequency OGSE to infer on S/V from the associated power law dependence (1/ω^1/2,) and the Standard Model with Exchange (SMEX) model for extracting the neurite -> extracellular space exchange rates in stroked rat brains. Combined, we present quantitative measurements of permeability which show plausible values and striking contrast in stroke.

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