Abstract #0968

Assessing Muscle Invasiveness In Bladder Cancer Based On Multiple Diffusion Models

Junting Guo¹, Lu Zhang¹, Shuo Li¹, Ding Li¹, Zhichang Fan¹, Meining Chen², Guoqiang Yang³, Yan Li³, Bin Wang³, Le Wang³, and Xiaochun Wang³

¹College of Medical Imaging, Shanxi Medical University, Taiyuan, China, ²MR Scientific Marketing, Siemens Healthcare, Shanghai, China, ³Department of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, CancerAccurate assessment of the presence or absence of muscle invasiveness in bladder cancer is essential for selecting the best treatment options. In this study, we used 6 diffusion models including mono-exponential model (Mono), continuous-time random-walk (CTRW), incoherent motion within the voxel (IVIM), stretched exponential model (SEM), diffusion kurtosis imaging (DKI) and fractional-order calculus (FROC) model to assess muscle invasiveness in bladder cancer. The study showed that Mono,CTRW,IVIM,SEM and DKI could provide biomarkers for muscle invasion and distinguish non-muscle-invasive and muscle-invasive bladder cancer, and the combination of CTRW and FROC could further improve the classification accuracy.

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