Abstract #0974

Diffusion simulations in human myelinated axons from 3d EM evaluate the impact of realistic axon geometry on diameter mapping

Hong-Hsi Lee^1,2, Qiyuan Tian^1,2, Ricardo Coronado-Leija³, Els Fieremans³, Dmitry S Novikov³, and Susie Y Huang^1,2

¹Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Center for Advanced Imaging Innovation and Research, New York University School of Medicine, New York, NY, United States

Synopsis

Keywords: Validation, MicrostructureTo disentangle the effect of complex features on axon diameter mapping, we segmented myelinated axons in a human brain electron microscopy data and use these to create artificial cylinders with undulations and caliber variations that can be tuned to varying degrees. Diffusion simulations in segmented real axons and artificial axons showed that undulations and beadings lead to overestimation and underestimation of the axon diameter, respectively.

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