Abstract #0975

Incorporating susceptibility effects into the Standard Model of diffusion in white matter

Anders Dyhr Sandgaard¹, Valerij G. Kiselev², Noam Shemesh³, and Sune Nørhøj Jespersen^1,4

¹Center for functionally integrative neuroscience, department of clinical medicine, Aarhus University, Aarhus, Denmark, ²Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ³Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, ⁴Department of Phsysics and Astronomy, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Microstructure, Diffusion/other diffusion imaging techniquesEstimating parameters of the Standard Model (SM) of white matter (WM) is an ill-posed problem (WM). To overcome this degeneracy, models extensions have been proposed adding echo-time dependent information. Here we investigate the feasibility of incorporating our analytical solution for the frequency shift from white matter axons accounting for magneto-structural anisotropy along with an empirical orientation dependence of relaxation into SM parameter estimation. This may also help achieving rotation-free mapping of susceptibility-related parameters using diffusion MRI instead of the impractical sample rotation in the scanner.

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