Abstract #0995
Detecting in vivo Mitochondrial Dysfunction with 4D Oxy-wavelet MRI in Kainic Acid Induced Temporal Lobe Epilepsy
Devin Raine Everaldo Cortes1,2,3, Margaret C. Stapleton2,3, Kristina E. Schwab4,5, Noah W. Coulson2,6, Dalton R West2,3, Thomas Becker-Szurszewski4,5, Sean Hartwick4,5, Sivakama S. Bharathi7, Eric Goetzman7, Kevin M. Kelly8, Anthony G. Christodoulou9, and Yijen L Wu1,2,3,7
1Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 3Rangos Research Center Small Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 4Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 5Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, 6Rangos Research Center Small Animal Imaging Core, University of Pittsburgh, Pittsburgh, PA, United States, 7Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 8Allegheny Health Network Research Institue, Allegheny General Hospital, Pittsburgh, PA, United States, 9Biomedical Imaging Research Institue, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Synopsis
Keywords: Epilepsy, Metabolism, fMRI, HypoxiaIntractable temporal lobe epilepsy, often acquired after status epilepticus (SE) injury, greatly reduces quality of life. There is an unmet need for a non-invasive method to track progression from SE to epilepsy, which would allow early intervention to prevent irreversible damage to the brain. Mitochondrial dysfunction is becoming a recognized marker of epileptogenesis. Here, we established a novel functional MRI methodology, the 4D Oxy-wavelet MRI, capable of in vivo detection of mitochondrial dysfunction underlying post-SE epileptogenesis in a spatial specific manner. This non-invasive method may aid early detection of subclinical epileptogenesis and serve as a biomarker for therapeutic efficacy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
