Abstract #0997

7T metabolic MRI in mesial temporal lobe epilepsy

Sarah M Jacobs¹, Zahra Shams¹, Anja G van der Kolk^1,2, Alex Bhogal¹, Jannie P Wijnen¹, Jeroen C.W. Siero^1,3, Pieter van Eijsden⁴, Edwin Versteeg¹, Angelika Mühlebner^5,6, Wim Van Hecke⁵, Dennis WJ Klomp¹, Maeike Zijlmans^4,7, and Evita C Wiegers¹

¹Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands, ³Spinoza Centre for Neuroimaging Amsterdam, Amsterdam, Netherlands, ⁴UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Department of Pathology, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, ⁷Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands

Synopsis

Keywords: Epilepsy, MetabolismWe combined quantitative susceptibility mapping (QSM) and single voxel (SV) 1H magnetic resonance spectroscopy (MRS) at 7 tesla (7T) with the aim to characterize mesial temporal lobe epilepsy (mTLE). We discovered in 9 patients that the distribution of quantified susceptibly is negatively skewed in epileptogenic hippocampi compared to contralateral hippocampi, meaning more positive susceptibility values: an indicator for iron deposition. No differences in metabolite ratios could be seen in 7 patients between hippocampi, however our small sample size precludes any final conclusions.

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