Abstract #0999

Structural changes within the temporal lobe in mesial temporal lobe epilepsy at 7 Tesla

Mackenzie Langan^1,2, Gauarv Verma², Madeline Fields³, Lara Marcuse³, Priti Balchandani^2,4,5, and Rebecca Feldman^2,6

¹Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Neurology, Mount Sinai Hospital, New York, NY, United States, ⁴Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁶Computer Science, Math, Physics, and Statistics, University of British Columbia, Kelowna, BC, Canada

Synopsis

Keywords: Epilepsy, Neuroinflammation, High-Field MRI, perivascular spacesHere we outline a preliminary analysis using a novel method leveraging ultra-high field neuroimaging to measure detectable differences in vasculature within the temporal lobe that may not be detectable at lower field strengths. We provide a tool for detection and quantification of vessels, perivascular spaces, and volumetric changes within the temporal lobe which may be relevant to uncover possible underlying neuroinflammatory processes in mesial temporal lobe epilepsy (MTLE) patients. In our analysis, we found a significant association between volumetric measures of the temporal lobe and vascular and perivascular markers, in patients with lateralized MTLE which may underlie epileptogenic processes.

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