Abstract #1001

A 15-minute 860um whole-brain MR-Fingerprinting and DTI epilepsy protocol demonstrated on 51 medial temporal lobe epilepsy patients.

Kang Wang¹, Xiaozhi Cao^2,3, Quan Chen^2,3, Zihan Zhou⁴, Dengchang Wu¹, Yunsong Liu⁵, Hongjian He⁴, Jianhui Zhong^4,6, Kawin Setsompop^2,3, and Congyu Liao^2,3

¹Department of Neurology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ²Department of Radiology, Stanford University, Stanford, CA, United States, ³Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ⁴Center for Brain Imaging Science and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ⁵Signal and Image Processing Institute, University of Southern California, Los Angeles, CA, United States, ⁶Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Synopsis

Keywords: Epilepsy, EpilepsyIn this work, we combined a 5-minute whole-brain 0.86mm-iso 3D-MR fingerprinting (MRF) with a 10-minute whole-brain 0.86mm-iso diffusion MRI protocol, to achieve high-fidelity whole-brain T₁/T₂/PD and diffusivity maps at sub-millimeter isotropic resolution. This protocol was applied to medial temporal lobe epilepsy (MTLE) patients to enable accurate detection of the hippocampal sclerosis. A multi-parametric analysis was implemented with whole-brain subcortical segmentation. A multi-component 2D-relaxometry spectra was estimated with non-negative joint sparsity for robust suspicious lesion detection.

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